DNA hypomethylation is an important epigenetic modification found to occur in many different cancer types. leading to the upregulation of previously silenced genes and loss of genomic stability. We previously demonstrated that hypoxia and hypoglycaemia (ischemia). two common micro-environmental changes in solid tumours. https://thebrickes.shop/product-category/planter/
Genome-wide analysis in human colorectal cancer cells reveals ischemia-mediated expression of motility genes via DNA hypomethylation.
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