Abstract We present a robust method called improved-Genome editing via Oviductal Nucleic Acids Delivery (i-GONAD) that delivers CRISPR ribonucleoproteins to E0. 7 embryos via in situ electroporation. The method generates mouse models containing single-base changes. kilobase-sized deletions. https://lecoureures.shop/product-category/course-a-pied-accessoires-nutrition/